Biphasic Isophane Insulin Pharmacology 

Biphasic Isophane Insulin
Biphasic Isophane Insulin
Antidiabetic, A mixture of fast acting and intermediate acting agent
Antidiabetic, A mixture of fast acting and intermediate acting agent
Binding to insulin receptors on cells in the body. Insulin causes cells in the liver, muscle and fat tissue to increase their uptake of glucose form the bloodstream. It also decreases the production of glucose by the liver
Binding to insulin receptors on cells in the body. Insulin causes cells in the liver, muscle and fat tissue to increase their uptake of glucose form the bloodstream. It also decreases the production of glucose by the liver
Absorption: Administered subcutaneously
Distribution: It is widely distributed through out the body Metabolism: It is metabolized in liver, muscle and kidney
Absorption: Administered subcutaneously
Distribution: It is widely distributed through out the body Metabolism: It is metabolized in liver, muscle and kidney
Absorption: Administered subcutaneously
Distribution: It is widely distributed through out the body Metabolism: It is metabolized in liver, muscle and kidney
Absorption: Administered subcutaneously
Distribution: It is widely distributed through out the body Metabolism: It is metabolized in liver, muscle and kidney
N/A
N/A
5 to 10 hrs
5 to 10 hrs
Hypoglycaemia
Local or systemic allergic reactions 3.Diabetic retinopathy
4.Swollen joints 5.Painful neuropathy
6.Visual disturbances
Hypoglycaemia
Local or systemic allergic reactions 3.Diabetic retinopathy
4.Swollen joints 5.Painful neuropathy
6.Visual disturbances
Hypoglycaemia
Hypoglycaemia
N/A
N/A
Use with caution
Use with caution
N/A
N/A
Use with caution
Use with caution
N/A
N/A
Treatment of DM
Treatment of DM
ACE inhibitors, Anabolic steroids, Antidiabetic medicines taken by mouth, MAOI antidepressants, Large doses of salicylates: Insulin isophane effect increased by these drugs
Chlorpromazine, Olanzapine Corticosteroids (eg Hydrocortisone, Prednisolone), Danazol Diuretics, Lithium, Isoniazid, Protease inhibitors ( eg ritonavir), somatropin (human growth hormone):Insulin isophane effect
reduced by these drugs
ACE inhibitors, Anabolic steroids, Antidiabetic medicines taken by mouth, MAOI antidepressants, Large doses of salicylates: Insulin isophane effect increased by these drugs
Chlorpromazine, Olanzapine Corticosteroids (eg Hydrocortisone, Prednisolone), Danazol Diuretics, Lithium, Isoniazid, Protease inhibitors ( eg ritonavir), somatropin (human growth hormone):Insulin isophane effect
reduced by these drugs
SC individualised dosage
SC individualised dosage
N/A
N/A
Store at 2-8?C (in a refrigerator). Do not freeze.Protect from direct heat and light.Keep out of the reach of
children.
Store at 2-8?C (in a refrigerator). Do not freeze.Protect from direct heat and light.Keep out of the reach of
children.
N/A
N/A