Bethanechol Chloride Pharmacology 

Bethanechol Chloride
Bethanechol Chloride
Cholinergic agonist, urinary tract and GI tract stimulant.
Cholinergic agonist, urinary tract and GI tract stimulant.
It stimulates “Muscarinic cholinergic receptors” in the autonomic nervous system. This muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. These receptors are found all over the body, including the muscle which surrounds the bladder and the muscles of the gastro- intestinal tract. Stimulation of the bladder muscle receptors enables the bladder to empty while stimulation of the esophageal (gullet) muscles prevents the reflux of stomach contents.
It stimulates “Muscarinic cholinergic receptors” in the autonomic nervous system. This muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. These receptors are found all over the body, including the muscle which surrounds the bladder and the muscles of the gastro- intestinal tract. Stimulation of the bladder muscle receptors enables the bladder to empty while stimulation of the esophageal (gullet) muscles prevents the reflux of stomach contents.
Absorption- Poorly absorbed after oral administration
Absorption- Poorly absorbed after oral administration
Absorption- Poorly absorbed after oral administration
Absorption- Poorly absorbed after oral administration
6 hours after large doses and 2 hours after subcutaneous administration
6 hours after large doses and 2 hours after subcutaneous administration
N/A
N/A
Blurred vision.
Vomiting.
Nausea.
Sweating.
Fluctuating abdominal pain (colic)
Blurred vision.
Vomiting.
Nausea.
Sweating.
Fluctuating abdominal pain (colic)
Hypersensitivity to the drug or its ingredient.
Blockage of the gut (intestinal obstruction).
Obstruction of the urinary tract (urethra).
Recent heart attack
Recent surgical procedure. 6 Bradycardia. 7.Hypotension.
8. Epilepsy. 9.Parkinsonism. 10.Peptic ulcer.
11.Vasomotor instability.
Hypersensitivity to the drug or its ingredient.
Blockage of the gut (intestinal obstruction).
Obstruction of the urinary tract (urethra).
Recent heart attack
Recent surgical procedure. 6 Bradycardia. 7.Hypotension.
8. Epilepsy. 9.Parkinsonism. 10.Peptic ulcer.
11.Vasomotor instability.
Urinary retention, if the sphincter fails to relax as bethanechol contracts the bladder, urine may be forced up the ureter into the kidney pelvis
Bacteriuria, this may cause reflux infection.
Urinary retention, if the sphincter fails to relax as bethanechol contracts the bladder, urine may be forced up the ureter into the kidney pelvis
Bacteriuria, this may cause reflux infection.
Use with caution
Use with caution
Use with caution.
Use with caution.
Use with caution
Use with caution
Use with caution
Use with caution
Acute postoperative and postpartum nonobstructive (functional) urinary retention.
Neurogenic atony of the urinary bladder with retention.
Heartburn
Acute postoperative and postpartum nonobstructive (functional) urinary retention.
Neurogenic atony of the urinary bladder with retention.
Heartburn
Ganglion blocking compounds may cause severe fall in B.P. Cholinergic drugs: Additive effect may occur.
Quinidine, Procainamide: May antagonize cholinergic effects of bethanechol.
Ganglion blocking compounds may cause severe fall in B.P. Cholinergic drugs: Additive effect may occur.
Quinidine, Procainamide: May antagonize cholinergic effects of bethanechol.
Oral- Adults-
10-25mg 3-4 times daily either 1 hour before or 2 hours after meals
Oral- Adults-
10-25mg 3-4 times daily either 1 hour before or 2 hours after meals
H
H
Store at room temperature; avoid freezing
Store at room temperature; avoid freezing
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.