Betamethasone (Nasal) Pharmacology 

Betamethasone (Nasal)
Betamethasone (Nasal)
Glucocorticoid steroid, seasonal or perennial allergic and nonallergic (vasomotor) .
Glucocorticoid steroid, seasonal or perennial allergic and nonallergic (vasomotor) .
Betamethasone exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: – 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM- 1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.Betamethasone can be given as a nasal spray
to treat and prevent the inflammation that can occur in conditions such as allergies.
Betamethasone exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: – 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM- 1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.Betamethasone can be given as a nasal spray
to treat and prevent the inflammation that can occur in conditions such as allergies.
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1.Bronchospasm 2.Epistaxis
3.Smell and taste disturbances 4.Irritation of the tissues in the nose 5.Dryness of the nose and throat
6.Local sensitivity reactions
1.Bronchospasm 2.Epistaxis
3.Smell and taste disturbances 4.Irritation of the tissues in the nose 5.Dryness of the nose and throat
6.Local sensitivity reactions
1.Perforated ear drum 2.After nasal surgery
3.Tuberculosis
1.Perforated ear drum 2.After nasal surgery
3.Tuberculosis
Glaucoma
Herpes-type infection of the eye infection 3.Recent nasal surgery
4.Nasal sores 5.Liver disease 6.Tuberculosis
7.Underactive thyroid
Glaucoma
Herpes-type infection of the eye infection 3.Recent nasal surgery
4.Nasal sores 5.Liver disease 6.Tuberculosis
7.Underactive thyroid
Contraindicated
Contraindicated
Use with caution
Use with caution
Contraindicated
Contraindicated
Use with caution
Use with caution
Otitis externa
Non-allergic rhinitis
Otitis externa
Non-allergic rhinitis
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Appy the medicament as directed by the Physician
Appy the medicament as directed by the Physician
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Store this medication at room temperature away from moisture and heat.Keep out of the reach of children.
Store this medication at room temperature away from moisture and heat.Keep out of the reach of children.
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.