Betahistine Pharmacology 

Betahistine
Betahistine
H1 selective histamine analogue, diamine oxidase inhibitor, anti vertigo and in Meniere?s syndrome.
H1 selective histamine analogue, diamine oxidase inhibitor, anti vertigo and in Meniere?s syndrome.
Betahistine is a histamine substitute. It produces vasodilatation and improves blood flow to the labyrinth and brain stem. There by it reduces the frequency of episodes of vertigo in patient with Meniere`s syndrome.
It works directly on histamine receptors. These receptors are found in blood vessel walls including those in the ear. Activation of these receptors will results in the widening of blood vessels. This improves circulation reducing the pressure in the ear. Its main use is in treating Meniere`s disease. It helps in relieving the inner ear pressure and by reducing the frequency and severity of nausea and vertigo attacks. It also reduces tinnitus thus helping to restore normal hearing.
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Betahistine is a histamine substitute. It produces vasodilatation and improves blood flow to the labyrinth and brain stem. There by it reduces the frequency of episodes of vertigo in patient with Meniere`s syndrome.
It works directly on histamine receptors. These receptors are found in blood vessel walls including those in the ear. Activation of these receptors will results in the widening of blood vessels. This improves circulation reducing the pressure in the ear. Its main use is in treating Meniere`s disease. It helps in relieving the inner ear pressure and by reducing the frequency and severity of nausea and vertigo attacks. It also reduces tinnitus thus helping to restore normal hearing.
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Absorption: It is very rapidly absorbed after oral administration. Metabolism: Betahistine is rapidly metabolised
in the liver to 2-pyridylacetic acid. Excretion: Excreted mainly in urine
Absorption: It is very rapidly absorbed after oral administration. Metabolism: Betahistine is rapidly metabolised
in the liver to 2-pyridylacetic acid. Excretion: Excreted mainly in urine
Absorption: It is very rapidly absorbed after oral administration. Metabolism: Betahistine is rapidly metabolised
in the liver to 2-pyridylacetic acid. Excretion: Excreted mainly in urine
Absorption: It is very rapidly absorbed after oral administration. Metabolism: Betahistine is rapidly metabolised
in the liver to 2-pyridylacetic acid. Excretion: Excreted mainly in urine
6-12 hours.
6-12 hours.
3.5 hours
3.5 hours
1.Headache 2.Rashes 3.Pruritis
4.Gastrointestinal disturbances 5.Nausea
6.Urticaria 7.Dizziness 8.Insomnia
9.Dyspepsia
1.Headache 2.Rashes 3.Pruritis
4.Gastrointestinal disturbances 5.Nausea
6.Urticaria 7.Dizziness 8.Insomnia
9.Dyspepsia
Hypersensitivity to Betahistine
Pheochromocytoma
Hypersensitivity to Betahistine
Pheochromocytoma
1.Asthma 2.Ulcer
3.Patient receiving antihistamines
1.Asthma 2.Ulcer
3.Patient receiving antihistamines
Use with caution.
Use with caution.
Use with caution.
Use with caution.
Use with caution.
Use with caution.
Contraindicated
Contraindicated
Meniere`s syndrome
Vertigo
Meniere`s syndrome
Vertigo
Antihistaminics : Betahistine dihydrochloride antagonises the effects of antihistaminics
Antihistaminics : Betahistine dihydrochloride antagonises the effects of antihistaminics
Adult: 8 mg 3 times daily with meals. Dose can be increased if needed to 48 mg / day.
Children: not recommended
Adult: 8 mg 3 times daily with meals. Dose can be increased if needed to 48 mg / day.
Children: not recommended
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Store at room temperature. Protect from light and moisture.
Store at room temperature. Protect from light and moisture.
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue
the regular schedule. Do not double the dose.