Benztropine Pharmacology 

Benztropine
Benztropine
Anticholinergic(Antimuscarinic),Antihistaminic
Anticholinergic(Antimuscarinic),Antihistaminic
Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson’s disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth
control of voluntary muscle movement
Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson’s disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth
control of voluntary muscle movement
Absorption: Absorbed after oral, IM, IV
Distribution: Protein binding about 95%; crosses blood brain barrier
Metabolism: Hepatic metabolism by N-oxidation, N-dealkylation, and ring hydroxylation
Absorption: Absorbed after oral, IM, IV
Distribution: Protein binding about 95%; crosses blood brain barrier
Metabolism: Hepatic metabolism by N-oxidation, N-dealkylation, and ring hydroxylation
Absorption: Absorbed after oral, IM, IV
Distribution: Protein binding about 95%; crosses blood brain barrier
Metabolism: Hepatic metabolism by N-oxidation, N-dealkylation, and ring hydroxylation
Absorption: Absorbed after oral, IM, IV
Distribution: Protein binding about 95%; crosses blood brain barrier
Metabolism: Hepatic metabolism by N-oxidation, N-dealkylation, and ring hydroxylation
6-48 hr
6-48 hr
N/A
N/A
1.Nausea 2.Vomiting 3.Dry mouth
4.Allergic reaction constipation 5.Toxic psychosis
Numbness of fingers
Blurred vision
1.Nausea 2.Vomiting 3.Dry mouth
4.Allergic reaction constipation 5.Toxic psychosis
Numbness of fingers
Blurred vision
Prostatic hypertrophy
Myasthenia gravis
Prostatic hypertrophy
Myasthenia gravis
1.Heart problem 2.Liver problem 3.Kidney problem
4.GI disease
1.Heart problem 2.Liver problem 3.Kidney problem
4.GI disease
Use with caution
Use with caution
Use with caution
Use with caution
Use with caution
Use with caution
<3 yrs: Contraindicated <3 yrs: Contraindicated Ideopathic parkinsonism Postencephalitic parkinsonism 3.Acute dystonic reactions Ideopathic parkinsonism Postencephalitic parkinsonism 3.Acute dystonic reactions