| Azatadine Pharmacology |
| Azatadine |
| About Azatadine |
| H1antagonist, anti-serotonin, anticholinergic (drying), Antihistamine. |
| Mechanism of Action of Azatadine |
| Azatadine acts by blocking the binding of histamine to receptors in the body. It does not prevent the actual release of histamine from mast cells. By blocking the binding of histamine, the release of other chemicals and increased blood supply to the area is prevented or decreased. This results in prevention or relief of the typical symptoms of an allergic reaction |
| Pharmacokinets of Azatadine |
| Absorption- Well absorbed after oral administration Distribution- Widely distributed in the body Metabolism- Metabolized in the liver to its metabolites Excretion- Excreted via urine |
| Onset of Action for Azatadine |
| 1-2 hrs |
| Duration of Action for Azatadine |
| 12 hrs |
| Half Life of Azatadine |
| 12 hrs |
| Side Effects of Azatadine |
| 1. Difficulty breathing 2. Sleepiness 3. Fatigue 4. Dizziness 5. Headache 6. Dry mouth 7. Difficulty urinating 8. Enlarged prostate 9. Nervousness 10. Arthralgia 11. Pharyngitis 12. Increased appetite 13. Nausea 14. Weight gain 15. Diarrhea. |
| Contra-indications of Azatadine |
| 1. Hypersensitivity to the drug 2. Glaucoma or increased pressure in the eye 3. Stomach ulcer 4. Enlarged prostate 5. Bladder problems 6. Difficulty urinating 7. Hyperthyroidism 8. Heart diseases 9. Asthma 10. MAO inhibitors therapy |
| Special Precautions while taking Azatadine |
| 1. Any work which require mental alertness such as driving, operating machinery, or performing other hazardous activities 2. Alcohol dependence 3. Liver disease 4. Kidney disease 5. Peptic ulcer 6. Epilepsy 7. Pyloroduodenal ulcer |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution NEONATES- Contraindicated |
| Indications for Azatadine |
| 1. Rhinitis. 2. Pruritis. 3. Urticaria. 4. Insect bites or stings. |
| Interactions for Azatadine |
| MAOIs & TCAs: Enhance anticholinergic side effects of azatadine. Alcohol & Other CNS depressants: CNS depression potentiated. Betahistine: Antagonises effects of azatadine. Antimuscarinics: Increased antimuscarinic side effects. |
| Typical Dosage for Azatadine |
| Adult- 1 tab/day Or 2 tab twice a day (in severe cases) Children- 6-12 yrs – ? to 1 tab twice a day 1-6 yrs- ? tsp twice a day |
| Schedule of Azatadine |
| H |
| Storage Requirements for Azatadine |
| Stored at room temperature away from moisture and heat. |
| Effects of Missed Dosage of Azatadine |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Azatadine |
| Give symptomatic and supportive treatment |