| Auranofin (Gold) Pharmacology |
| Auranofin (Gold) |
| About Auranofin (Gold) |
| Organogold Compound, Antirheumatic. |
| Mechanism of Action of Auranofin (Gold) |
| It appears to reduce immune responsiveness. It inhibits the migration of mononuclear cells in area of inflammation. It also stabilize lysosomal membrane, hence damage to cartilage is prevented. |
| Pharmacokinets of Auranofin (Gold) |
| Absorption- 20-25% absorbed after oral administration Distribution- Widely distributed in the body Excretion- Excreted via urine and feces |
| Onset of Action for Auranofin (Gold) |
| N/A |
| Duration of Action for Auranofin (Gold) |
| N/A |
| Half Life of Auranofin (Gold) |
| Its plasma half life is 26 days |
| Side Effects of Auranofin (Gold) |
| 1. Dermatitis 2. Stomatitis 3. Glossitis 4. Pharyngitis 5. Pruritis 6. Exfoliative dermatitis 7. Peripheral neuritis 8. Thrombocytopenia 9. Leucopenia 10. Renal damage 11. Hepatic damage 12. Encephalopathy 13. Stiffness 14. Muscle aches 15. Fatigue 16. Nausea 17. Vomiting 18. Weakness 19. Sweating 20. Palpitation 21. Flushing 22. Joint pain |
| Contra-indications of Auranofin (Gold) |
| 1. Hypersensitivity to the gold 2. Hepatic dysfunction 3. Renal disease 4. History of infectious hepatitis 5. History of exfoliative dermatitis 6. Necrotizing enterocolitis 7. Bone marrow aplasia 8. Pulmonary fibrosis 9. Haematological disorders |
| Special Precautions while taking Auranofin (Gold) |
| Monitor blood counts & urinary protein regularly Use with caution in patients with Women in reproductive age group (should use effective contraception during therapy and up to six months after therapy is stopped). |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Auranofin (Gold) |
| 1. Rheumatoid arthritis 2. Juvenile arthritis |
| Interactions for Auranofin (Gold) |
| Phenytoin: Increase in phenytoin blood levels may occur. Other nephrotoxic drugs: Increased risk of toxicity. |
| Typical Dosage for Auranofin (Gold) |
| Oral- Adults- 6mg daily in two divided doses or as a single dose for minimum 3-6 months If response is inadequate increase to maximum 3mg thrice daily Intramuscular- Adult- Test dose- 10mg Weekly dose – 50mg In patient showing response doses should be increased gradually to 4 weeks and treatment continued for up to 5 years after complete remission. |
| Schedule of Auranofin (Gold) |
| H |
| Storage Requirements for Auranofin (Gold) |
| Store at room temperature, sealed, light- resistant container. |
| Effects of Missed Dosage of Auranofin (Gold) |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Auranofin (Gold) |
| Give symptomatic and supportive treatment. Adminitser corticosteroid, Dimercaprol or penicillamine for the recovery. If needed Dimercaprol give together with corticosteroids to facilitate the removal of gold. |