| Arteether Pharmacology |
| Arteether |
| About Arteether |
| Semi synthetic derivative of artemisinine, Fast acting blood schizontocide, Anti malarial. |
| Mechanism of Action of Arteether |
| It is a schizonticidal drug. The endoperoxide bridges in Artemether are cleaved by the binding of haeme and liberate highly active free radicals. These radicals bind to membrane proteins and cause lipid peroxidation and damages endoplasmic reticulum. It also inhibits protein synthesis and lysis of the parasite. |
| Pharmacokinets of Arteether |
| Absorption: Artemether is orally well absorbed. Distribution: It is distributed in plasma protein bound form. Metabolism: It is metabolised in the liver to active dihydro artemisnin |
| Onset of Action for Arteether |
| N/A |
| Duration of Action for Arteether |
| N/A |
| Half Life of Arteether |
| 1 – 2 days |
| Side Effects of Arteether |
| 1.Nausea 2.Vomiting 3.Diarrhoea 4.Abdominal pain 5.Reduction in eosinophil count |
| Contra-indications of Arteether |
| 1.Hypersensitivity to Arteether and other artemisnin derivative |
| Special Precautions while taking Arteether |
| 1.Renal impairment 2.Hepatic impairment 3.Cardiac failure 4.Monitor patients on concomitant use of drugs which cause prolongation of QT intervals |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Arteether |
| Chloroquine resistant malaria, complicated falciparum malaria and cerebral malaria. |
| Interactions for Arteether |
| N/A |
| Typical Dosage for Arteether |
| Adult (IM): 150 mg once daily for 3 days Children (IM): 3mg/kg body weight /day for 3 days |
| Schedule of Arteether |
| H |
| Storage Requirements for Arteether |
| Store in a cool dark place. Keep out of the reach of children. |
| Effects of Missed Dosage of Arteether |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose. |
| Effects of Overdose of Arteether |
| Give supportive measures and symptomatic treatment. |