| Anti-D Immune Globulin Pharmacology |
| Anti-D Immune Globulin |
| About Anti-D Immune Globulin |
| Anti Rhesus disease medicine, IgG type antibody. |
| Mechanism of Action of Anti-D Immune Globulin |
| Rh sensitization may occur in nonsensitized Rho(D) negative women following transplacental hemorrhage resulting from spontaneous or induced abortions.1-2 The risk of sensitization is higher in women undergoing induced abortions than in those aborting spontaneously.1-3 Anti-D Immune Globulin is used to prevent the formation of anti-Rho(D) antibody in Rho(D) negative women who are exposed to the Rho(D) antigen at the time of spontaneous or induced abortion (up to 12weeks? gestation). Anti-D Immune Globulin suppresses the stimulation of active immunity by Rho(D) positive fetal erythrocytes that may enter the maternal circulation at the time of termination of the pregnancy. |
| Pharmacokinets of Anti-D Immune Globulin |
| Distribution: Vd; 8.59 lit |
| Onset of Action for Anti-D Immune Globulin |
| N/A |
| Duration of Action for Anti-D Immune Globulin |
| N/A |
| Half Life of Anti-D Immune Globulin |
| 24-28 days |
| Side Effects of Anti-D Immune Globulin |
| 1.Headache 2.Fever (pyrexia) 3.Skin reactions such as rash and itch 4.A general feeling of being unwell (malaise) 5.Pain, soreness or bruising at the injection site |
| Contra-indications of Anti-D Immune Globulin |
| 1.Individuals whose blood type is rhesus (RhD) positive 2.Hypersensitivity |
| Special Precautions while taking Anti-D Immune Globulin |
| 1.People who have antibodies against immunoglobulin A (IgA) 2.People who have had atypical reactions following receipt of a blood transfusion or blood products. 3.Do not administer IM for ITP. 4.Avoid live vaccines for 3 month. 5.IgA deficiency |
| Pregnancy Related Information |
| Not recommended, it should be administered only postabortion or postmiscarriage |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Not recommended |
| Indications for Anti-D Immune Globulin |
| 1.It is recommended to prevent the isoimmunization of Rho(D) negative women at the time of spontaneous or induced abortion of up to 12 weeks? gestation provided the following criteria are met: a)The mother must be Rho(D) negative and must not already be sensitized to the Rho(D) antigen. b)The father is not known to be Rho(D) negative. c)Gestation is not more than 12 weeks at termination. 2.Preventing rhesus negative individuals who have received a rhesus positive blood transfusion from forming antibodies against the blood. |
| Interactions for Anti-D Immune Globulin |
| 1.People who have received anti-D immunoglobulin should not receive the measles, mumps and rubella (MMR) vaccine within the following three months, as the efficacy of this vaccine may be reduced if it is administered during this period. 2.If patient need to be given anti-D immunoglobulin within two to four weeks of receiving a live vaccine, such as yellow fever, rubella, BCG or oral polio, the anti-D immunoglobulin may reduce the efficacy of these vaccines. |
| Typical Dosage for Anti-D Immune Globulin |
| Asdirected by the physician |
| Schedule of Anti-D Immune Globulin |
| N/A |
| Storage Requirements for Anti-D Immune Globulin |
| Store at 2-8?C (36-46?F). Do not freeze. |
| Effects of Missed Dosage of Anti-D Immune Globulin |
| N/A |
| Effects of Overdose of Anti-D Immune Globulin |
| Patients who receive rho(d) immune globulin (human) for Rh-incompatible transfusion should be monitored by clinical and laboratory means due to the risk of a hemolytic reaction. |