| Anidulafungin Pharmacology |
| Anidulafungin |
| About Anidulafungin |
| Semi-synthetic lipopeptide ,Echinocandin(1,3-?-D-glucan synthesis inhibitor), anti fungal. |
| Mechanism of Action of Anidulafungin |
| Anidulafungin is an antifungal drug which inhibits the enzyme glucan synthase in the fungus which is used for the synthesis of 1, 3 beta D-glucan. Glucan is the essential component of fungal cell walls. |
| Pharmacokinets of Anidulafungin |
| Absorption: It is completely absorbed after parenteral administration. Distribution: It is widely distributed in the body in protein bound form. Excretion: It is excreted mainly in faeces. |
| Onset of Action for Anidulafungin |
| N/A |
| Duration of Action for Anidulafungin |
| N/A |
| Half Life of Anidulafungin |
| 40 -50 hours |
| Side Effects of Anidulafungin |
| 1.Rash 2.Urticaria 3.Flushing 4.Pruritus 5.Dyspnea 6.Hypotension |
| Contra-indications of Anidulafungin |
| Hypersensitivity to Anidulafungin |
| Special Precautions while taking Anidulafungin |
| Hepatic impairment |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Contraindicated |
| Indications for Anidulafungin |
| 1.Candidemia 2.Intra abdominal abscess 3.Peritonitis 4.Eosophageal candidiasis |
| Interactions for Anidulafungin |
| N/A |
| Typical Dosage for Anidulafungin |
| Loading dose: 200mg/day as single dose, followed by 100mg depending on the severity of infection Eosophageal candidiasis: 100mg/day as single dose, followed by 50mg depending on the severity of infection |
| Schedule of Anidulafungin |
| N/A |
| Storage Requirements for Anidulafungin |
| Stored at 15 – 30 degree C. Keep out of the reach of children. |
| Effects of Missed Dosage of Anidulafungin |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Anidulafungin |
| Give supportive measures and symptomatic treatment. |