| Amoxycillin Pharmacology |
| Amoxycillin |
| About Amoxycillin |
| Semisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative. |
| Mechanism of Action of Amoxycillin |
| Amoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once. |
| Pharmacokinets of Amoxycillin |
| Absorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted in breast milk |
| Onset of Action for Amoxycillin |
| 60 -120 minutes |
| Duration of Action for Amoxycillin |
| 6-8 hours |
| Half Life of Amoxycillin |
| 60 minutes |
| Side Effects of Amoxycillin |
| 1.Aaphylaxis 2. Vomiting 3.Diarrhoea 4 Nausea 5.Rash 6.Urticaria 7.Thrombocytopenia 8.Nephritis 9.Seizure 10.Super infections. |
| Contra-indications of Amoxycillin |
| Hypersensitivity to Amoxicillin and other Penicillins. |
| Special Precautions while taking Amoxycillin |
| 1.Mononucleosis 2.Lymphatic leukaemia 3.HIV infections 4.Hepatic impairment 5.Renal impairment |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Use with caution |
| Indications for Amoxycillin |
| 1Urinary tract infections 2.Gonorrhoea 3 Meningitis 4.SABE 5.Respiratory tract infections 6.Septicemia 7.Soft tissue infections 8.Otitis media 9.Sinusitis 10.Tetanus 11.Biliarytract infections 12.Bronchitis 13.Salmonellosis 14.Typhoid 15.Gastroenteritis 16.Chlamydia infection 17.Paratyphoid fever 18.Dental infections |
| Interactions for Amoxycillin |
| Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy. Erythromycin, Tetracycline: Reduce efficacy. |
| Typical Dosage for Amoxycillin |
| ADULT: 250 – 500 mg three to four times daily. In severe infections dose can be increased to 3 – 6 g daily depending on the severity of infection. CHILDREN:125 – 250 mg three to four times a day depending on the severity of infection. |
| Schedule of Amoxycillin |
| H |
| Storage Requirements for Amoxycillin |
| It should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children. |
| Effects of Missed Dosage of Amoxycillin |
| Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose |
| Effects of Overdose of Amoxycillin |
| Give supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed. |