| Amlexanox Pharmacology |
| Amlexanox |
| About Amlexanox |
| Anti-Allergic Agents,Antiulcer agent (topical),Anti-inflammatory Agents(topical). |
| Mechanism of Action of Amlexanox |
| As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1. |
| Pharmacokinets of Amlexanox |
| Absorption: Systemic absorption occurs mostly via GI tract; absorption directly through the active ulcer is not significant. Metabolism: Metabolised to hydroxylated and conjugated metabolites. Excretion: Excreted in urine. |
| Onset of Action for Amlexanox |
| N/A |
| Duration of Action for Amlexanox |
| N/A |
| Half Life of Amlexanox |
| About 3.5 hr. |
| Side Effects of Amlexanox |
| 1.Application site reactions e.g. transient pain, stinging, burning, irritation, contact mucositis 2.Nausea 3.Diarrhea |
| Contra-indications of Amlexanox |
| N/A |
| Special Precautions while taking Amlexanox |
| 1.For topical use on mouth ulcers only. 2.Avoid contact with the eyes; rinse immediately if ocular contact occurs. 3.Wash hands before and after every application. 4.Discontinue treatment if rash or contact mucositis develops. 5.Seek medical advice if mouth ulcers have not healed after 10 days of treatment. 6.Effects have not been evaluated in immune-compromised patients. 7.Avoid excess dosage |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use lower initial dose for elderly patients |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Not to be used in children below age 12 |
| Indications for Amlexanox |
| Used as a paste in the mouth to treat aphthous ulcers(canker sores). |
| Interactions for Amlexanox |
| N/A |
| Typical Dosage for Amlexanox |
| N/A |
| Schedule of Amlexanox |
| N/A |
| Storage Requirements for Amlexanox |
| Topical/Cutaneous: Store at room temperature 15-30?C (59-86?F). |
| Effects of Missed Dosage of Amlexanox |
| N/A |
| Effects of Overdose of Amlexanox |
| N/A |