| Ambroxol Pharmacology |
| Ambroxol |
| About Ambroxol |
| Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver. |
| Mechanism of Action of Ambroxol |
| Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties. |
| Pharmacokinets of Ambroxol |
| N/A |
| Onset of Action for Ambroxol |
| N/A |
| Duration of Action for Ambroxol |
| N/A |
| Half Life of Ambroxol |
| N/A |
| Side Effects of Ambroxol |
| 1. Rhinorrhoea 2. Lacrimations 3. Allergic reactions 4. Gastric irritation. |
| Contra-indications of Ambroxol |
| Hypersensitivity to the Ambroxol hydrochloride or Bromhexine. |
| Special Precautions while taking Ambroxol |
| 1.Hepatic impairment 2.Renal impairment 3.Gastric and duodenal ulcer 4.Convulsive disorders |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Ambroxol |
| 1. As Expectorant and mucolytic 2. Conditions associated with production of viscid mucous 3. Bronchitis 4. Pharyngitis 5. Laryngitis 6. Rhinitis 7. Sinusitis 8. Asthmatic bronchitis 9. Mucous bronchiectasis 10. Chronic Pneumonia. |
| Interactions for Ambroxol |
| N/A |
| Typical Dosage for Ambroxol |
| Oral: 15mg to 30mg three times daily. Children (6 to 12years): 5ml 2 to 3 times daily Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride) Children up to 2 years: 7.5mg two times daily |
| Schedule of Ambroxol |
| H |
| Storage Requirements for Ambroxol |
| Store in a cool dry place and protect from light. Keep out of reach of children. |
| Effects of Missed Dosage of Ambroxol |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Ambroxol |
| Provide symptomatic treatment and supportive measures. |