| Aliskiren Pharmacology |
| Aliskiren |
| About Aliskiren |
| Antihypertensive, Non peptide renin inhibitor |
| Mechanism of Action of Aliskiren |
| Aliskiren inhibiting the enzyme renin, it prevents conversion of angiotensinogen into angiotensin I and therefore inhibits subsequent production of angiotensin II and aldosterone. Unlike ACE inhibitors and angiotensin II receptor antagonists which cause a compensatory rise in plasma renin activity, treatment with aliskiren decreases plasma renin activity and concentrations of angiotensin I, angiotensin II and aldosterone. |
| Pharmacokinets of Aliskiren |
| N/A |
| Onset of Action for Aliskiren |
| N/A |
| Duration of Action for Aliskiren |
| Long duration of action |
| Half Life of Aliskiren |
| 24 hrs |
| Side Effects of Aliskiren |
| 1.Angioedema 2.Hyperkalemia 3.Hypotension 4.Diarrhoea 5.Gastro-oesophageal reflux 6.Headache 7.Cough |
| Contra-indications of Aliskiren |
| N/A |
| Special Precautions while taking Aliskiren |
| 1.Renal impairment 2.Heart problem 3.Severe Diarrhoea |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Contraindicated |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Aliskiren |
| Hypertension |
| Interactions for Aliskiren |
| Irbesartan: Decreased aliskiren concentrations Atorvastatin and Ketoconazole: Increased aliskiren concentration Furosemide: Decreased furosemide concentration Potassium-sparing diuretics, Potassium supplements: Increased risk of hyperkalaemia |
| Typical Dosage for Aliskiren |
| Adult: ?18 yr: 150 mg once daily, increased to 300 mg once daily if needed |
| Schedule of Aliskiren |
| H |
| Storage Requirements for Aliskiren |
| Store between 15-30?C (59-86?F)in well closed container. Protect from moisture. Keep out of the reach of children. |
| Effects of Missed Dosage of Aliskiren |
| N/A |
| Effects of Overdose of Aliskiren |
| N/A |