| Adefovir Pharmacology |
| Adefovir |
| About Adefovir |
| Antiretroviral Agent, Reverse Transcriptase Inhibitor (Nucleoside) |
| Mechanism of Action of Adefovir |
| Adefovir undergoes phosphorylation in the presence of cellular kinase enzyme to Adefovir diphosphate. This Adefovir diphosphate competitively inhibits HBV DNA polymerase and reverse transcriptase enzyme by competing with nucleoside adenosine triphosphate and inhibits DNA synthesis. |
| Pharmacokinets of Adefovir |
| Absorption: It is absorbed after oral administration. Distribution: It is distributed in the body. Excretion: It is excreted mainly through urine. |
| Onset of Action for Adefovir |
| N/A |
| Duration of Action for Adefovir |
| N/A |
| Half Life of Adefovir |
| 8 hour |
| Side Effects of Adefovir |
| 1.Asthenia 2.Headache 3.Nausea 4.Diarrhoea 5.Abdominal pain 6.Flatulance 7.Dyspepsia 8.Fever 9.Rash 10.Increase in liver enzyme |
| Contra-indications of Adefovir |
| Hypersensitivity to Adefovir |
| Special Precautions while taking Adefovir |
| 1.Renal impairment 2.Hepatic impairment |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Contraindicated NEONATES: contraindicated |
| Indications for Adefovir |
| 1.Hepatitis B infection |
| Interactions for Adefovir |
| N/A |
| Typical Dosage for Adefovir |
| Adult: 10 mg / day |
| Schedule of Adefovir |
| H |
| Storage Requirements for Adefovir |
| The drug should be kept at 15 – 30 degree C in a tightly closed container. Protect away from heat and light. Keep out of the reach of children. |
| Effects of Missed Dosage of Adefovir |
| Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose. |
| Effects of Overdose of Adefovir |
| Give supportive measures and treatment |