| Acitretin Pharmacology |
| Acitretin |
| About Acitretin |
| Retinoid-Like Compound, Antipsoriatic. |
| Mechanism of Action of Acitretin |
| Acitretin is a second generation retinoid. It slows down the proliferation of the skin cells and is therefore used in psoriasis. Retinoic acid activates Retinoic acid receptors (RARs) and retinoic acid X receptors (RXRs) and produce effects on gene expression. Retinoid binds to transcription factors (nuclear receptors) and form complex. This complex binds to promoter regions of target genes and regulates their expressions. The gene product formed produce effective pharmacological actions. |
| Pharmacokinets of Acitretin |
| N/A |
| Onset of Action for Acitretin |
| N/A |
| Duration of Action for Acitretin |
| N/A |
| Half Life of Acitretin |
| N/A |
| Side Effects of Acitretin |
| 1.Dry mouth 2.Abdominal disturbances 3.Vomiting 4.Nausea 5.Headache 6.Shortness of breath 7.Decreased consciousness 8.Dryness of lips 9.Dry nostrils 10.Dry eyes 11.Dry reddened skin 12.Drowsiness 13.Peeling skin 14.Dry skin 15.Malaise 16.Weak nails 17.Dandruff 18.Sunburn 19.Abnormal skin odor 20.Excessive sweating 21.Hair loss 22.Changes in hair texture 23.Dry eyes 24.Loss of eyebrows or eyelashes 25.Hot flashes 26.Swollen lips 27.Bleeding gums 28.Excessive saliva 29.Mouth swelling 30.Stomach pain 31.Diarrhoea 32.Increased appetite 33.Sleep 34.Sinusitis 35.Rhinitis 36.Nosebleed 37.Joint pain 38.Tight muscles |
| Contra-indications of Acitretin |
| 1.Hepatic impairment 2.Renal impairment 3.Hyperlipidaemia |
| Special Precautions while taking Acitretin |
| 1.Diabetes 2.Avoid excessive exposure to sunlight |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Acitretin |
| 1.Psoriasis 2.Darier`s disease 3.Ichthyosis 4.Impetigo |
| Interactions for Acitretin |
| N/A |
| Typical Dosage for Acitretin |
| Adult: 25- 30mg / day for 14 – 28 days, then adjusted according to response. Maintenance dose: 25 – 50mg/day. Maximum dose: 75mg/day Darier`s disease: 10mg/day Children: 0.5 mg/kg daily dose can be increased to 1mg/kg daily. |
| Schedule of Acitretin |
| H |
| Storage Requirements for Acitretin |
| Store it at room temperature and away from excess heat and moisture. Keep out of reach of children. |
| Effects of Missed Dosage of Acitretin |
| Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose. Continue the regular dose. Do not double the dose. |
| Effects of Overdose of Acitretin |
| Give supportive measures and symptomatic treatment. |
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