| Aceclofenac Topical Pharmacology |
| Aceclofenac Topical |
| About Aceclofenac Topical |
| NSAID, Analgesic,anti-inflammatory,Anti arthritic – (Topical Preparation) |
| Mechanism of Action of Aceclofenac Topical |
| This drug has several mechanism of action. 1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). 2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines. 3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production. 4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen. 5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs. 6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils. 7. Aceclofenac is also an NSAID with greater COX-2 specificity |
| Pharmacokinets of Aceclofenac Topical |
| N/A |
| Onset of Action for Aceclofenac Topical |
| N/A |
| Duration of Action for Aceclofenac Topical |
| N/A |
| Half Life of Aceclofenac Topical |
| N/A |
| Side Effects of Aceclofenac Topical |
| 1. Dermatitis. 2. Local irritation. 3. Erythema. 4. Photosensitivity. 5. Pruritis |
| Contra-indications of Aceclofenac Topical |
| Contraindicated in patients with hypersensitivity to the drug |
| Special Precautions while taking Aceclofenac Topical |
| 1. Vitamin K deficiency 2. Hypothrombinemia 3. Liver disease 4. Before surgery 5. For external use only 6. NOT to be applied on wounds and broken skin 7. As the drugs in topical analgesics may produce irritation they should not be applied near eyes, on mucus membrane or on inflamed skin |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Use with caution |
| Indications for Aceclofenac Topical |
| 1. Muscle strains. 2. Sprains. 3. Bruises. 4. Overexertion. 5. Adjunct in the management of minor stiffness or soreness associated with arthritis. 6. Rheumatism. 7. Lumbago. 8. Fibrositis. 9. Sciatica. 10. Stiffneck. |
| Interactions for Aceclofenac Topical |
| N/A |
| Typical Dosage for Aceclofenac Topical |
| 30g Gel – 1.5% is available.Apply to the affected area 2-3 times daily. Rubbing or massaging should be usually avoided. |
| Schedule of Aceclofenac Topical |
| N/A |
| Storage Requirements for Aceclofenac Topical |
| Store at room temperature away from moisture and heat |
| Effects of Missed Dosage of Aceclofenac Topical |
| Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not apply a double dose of this medication. |
| Effects of Overdose of Aceclofenac Topical |
| Give symptomatic and supportive treatment |