Bleomycin Pharmacology 

Bleomycin
Bleomycin
A glycopeptide antibiotic Derivative Antineoplastic
A glycopeptide antibiotic Derivative Antineoplastic
It causes the fragmentation of DNA, RNA and inhibits the protein synthesis. It also inhibits the incorporation of thymine into DNA strands. Its DNA cleavage depends on oxygen and metal ions. Drug chelate the metal ion producing pseudo enzymes that react with oxygen to produce super oxide and hydroxide free radicals that cleave DNA.In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular
molecules
It causes the fragmentation of DNA, RNA and inhibits the protein synthesis. It also inhibits the incorporation of thymine into DNA strands. Its DNA cleavage depends on oxygen and metal ions. Drug chelate the metal ion producing pseudo enzymes that react with oxygen to produce super oxide and hydroxide free radicals that cleave DNA.In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular
molecules
Absorption -It is slow after subcutaneous administration. Rapidly absorbed after intravenous administration Distribution-Widely distributed in the body. <10% bound to the plasma proteins Metabolism -Metabolized in to its metabolites in the liver, kidney, lungs and skin. Excretion-Excreted through urine, feces and lungs Absorption -It is slow after subcutaneous administration. Rapidly absorbed after intravenous administration Distribution-Widely distributed in the body. <10% bound to the plasma proteins Metabolism -Metabolized in to its metabolites in the liver, kidney, lungs and skin. Excretion-Excreted through urine, feces and lungs Absorption -It is slow after subcutaneous administration. Rapidly absorbed after intravenous administration Distribution-Widely distributed in the body. <10% bound to the plasma proteins Metabolism -Metabolized in to its metabolites in the liver, kidney, lungs and skin. Excretion-Excreted through urine, feces and lungs Absorption -It is slow after subcutaneous administration. Rapidly absorbed after intravenous administration Distribution-Widely distributed in the body. <10% bound to the plasma proteins Metabolism -Metabolized in to its metabolites in the liver, kidney, lungs and skin. Excretion-Excreted through urine, feces and lungs N/A N/A Its plasma half life is about 2hrs. Its plasma half life is about 2hrs. Vomiting Painful or difficult urination Bruising or unusual bleeding Anemia Weakness sore in mouth Taste changes Diarrhea Loss of appetite Visual changes Black, tarry stools Blood in urine or in stool Cough or hoarseness Fever Chills Lower back or side pain Lymphoma Pinpoint red spot on skin Slurred speech Swelling on leg or lower leg Shortness of breath Pulmonary fibrosis Hepatotoxicity Alopecia Pneumonites Hypotension Wheezing Vomiting Painful or difficult urination Bruising or unusual bleeding Anemia Weakness sore in mouth Taste changes Diarrhea Loss of appetite Visual changes Black, tarry stools Blood in urine or in stool Cough or hoarseness Fever Chills Lower back or side pain Lymphoma Pinpoint red spot on skin Slurred speech Swelling on leg or lower leg Shortness of breath Pulmonary fibrosis Hepatotoxicity Alopecia Pneumonites Hypotension Wheezing Hypersensitivity to the drug Pulmonary diseases Hypersensitivity to the drug Pulmonary diseases Hypersensitivity to drug Anesthesia Lowered resistance to infection Monitor patient pulmonary function closely Hypersensitivity to drug Anesthesia Lowered resistance to infection Monitor patient pulmonary function closely Contraindicated. Contraindicated. Use with caution Use with caution Contraindicated Contraindicated