| Apomorphine Pharmacology |
| Apomorphine |
| About Apomorphine |
| Potent dopamine agonist, Anti-Parkinson`s Agent. |
| Mechanism of Action of Apomorphine |
| Apomorphine is a potent dopamine agonist. It is useful in advanced disease for patients experiencing unpredictable off periods with Levodopa treatment. |
| Pharmacokinets of Apomorphine |
| Absorption: It is well absorbed after subcutaneous administration. Distribution: It is widely distributed in the body. |
| Onset of Action for Apomorphine |
| N/A |
| Duration of Action for Apomorphine |
| N/A |
| Half Life of Apomorphine |
| 30 – 60 minutes |
| Side Effects of Apomorphine |
| 1.Nausea 2.Vomiting 3.Diarrhoea 4.Dyskinesia 5.Weakness 6.Dizziness 7.Confusion 8.Hallucinations 9.Constipation 10.Yawning 11.Drowsiness 12.Somnolence 13.Postural Hypotension 14.Rhinorrhea 15.Chest Pain 16.Edema 17.Swelling of Extremities 18.Arthralgia 19.Insomnia 20.Sedation 21.Euphoria 22.Light headedness 23.Restlessness 24.Tremor 25.Headache 26.Depression 27.Urinary tract infection 28.Anxiety 29.Congestive heart failure 30.Limb pain 31.Back pain 32.Pneumonia 33.Increased sweating 34.Dyspnea 35.Fatigue 36.Dehydration. |
| Contra-indications of Apomorphine |
| 1.Hypersensitivity to Apomorphine 2.Respiratory depression 3.CNS depression 4.Hepatic Impairment 5.Neuropsychiatric problems 6.Dementia 7.Severe dyskinesia 8.Hypotonia |
| Special Precautions while taking Apomorphine |
| 1.Renal Impairment 2.Pulmonary dysfunction 3.Cardiovascular diseases 4.Endocrine diseases 5.Hypotension 6.Dyskinesias 7.Fibrotic Complications 8.Priapism |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Contraindicated |
| Indications for Apomorphine |
| 1. “Off” episodes associated with advanced Parkinsons disease |
| Interactions for Apomorphine |
| N/A |
| Typical Dosage for Apomorphine |
| Subcutaneous: 3 – 30mg/day in divided doses depending on the response. Maximum dose: 100mg |
| Schedule of Apomorphine |
| N/A |
| Storage Requirements for Apomorphine |
| Store at room temperature. Keep out of the reach of children. |
| Effects of Missed Dosage of Apomorphine |
| Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Apomorphine |
| Give supportive measures and symptomatic treatment. |