| Analgin Pharmacology |
| Analgin |
| About Analgin |
| Pyrazolone derived NSAID, Antipyretic , Anti-inflammatory and analgesic. |
| Mechanism of Action of Analgin |
| This pyrazolone group containing Non Steroidal Anti Inflammatory Drug has potent analgesic, antipyretic and moderate anti inflammatory activity. It blocks the synthesis of pyrogens. It also reduces prostaglandin D &E synthesis by cyclo oxigenase enzyme inhibition. These peripheral interactions are the cause for its analgesic and antipyretic activity. There is a small fraction of reduction in sensitivity of nerve endings due to this decreased prostaglandin synthesis. Centrally it stimulate the synthesis of beta endorphin it cause the analgesic action on visceral pain. In the muscles of biliary tract, urinary tract and in uterus it has some spasmolytic activity. |
| Pharmacokinets of Analgin |
| Absorption-rapidly absorbed after oral, intravenous, and intramuscular administration. Distribution- widely distributed in the body Metabolism – metabolized in the liver to its metabolites. Excretion-Excreted via renal and non renal clearance |
| Onset of Action for Analgin |
| 30 to 60 minutes. |
| Duration of Action for Analgin |
| 3 to 6hrs |
| Half Life of Analgin |
| N/A |
| Side Effects of Analgin |
| 1. Agranulocytosis after prolonged application 2.thrombocytopenia 3. Leucopenia 4. Proteinuria 5. Intestinal nephrites 6. Rashes 7. Urticaria 8. Asthma 9. Quincke`s edema 10. Anaphylactoid shock 11. Hypotension following rapid injection 12. Neutropenia |
| Contra-indications of Analgin |
| 1. Hypersensitivity to metamizole and other pyrazolone derivatives 2. Hepatic porphyria 3. Inborn glucose-6-phosphate dehydrogenase 4. Renal or hepatic disease 5. Blood disorder. |
| Special Precautions while taking Analgin |
| 1. Bronchial asthma 2. Quinckes edema 3. Chronic pulmonary infection 4. Hyper sensitivity to food and other drugs 5. Care should be taken for parenteral administration in patients with hypotension and unstable blood pressure. |
| Pregnancy Related Information |
| N/A |
| Old Age Related Information |
| Use with cvaution |
| Breast Feeding Related Information |
| Use with caution. |
| Children Related Information |
| May be used Below 1 yrs parenteral administration should be given cautiously. |
| Indications for Analgin |
| 1. Toothache 2. Headache 3. Arthralgia 4. Neuralgia 5. Myositis 6. Visceral pain 7. High fever, not responding to other drugs 8. Post operative pain 9. Pain in trauma 10. Pain in cancer 11. Colicky pain 12. Febrile state 13. Rheumatism |
| Interactions for Analgin |
| Cyclosporine : Serum levels decreased. |
| Typical Dosage for Analgin |
| Adults- Oral- 500mg to 1g every 3 to 4 times Intramuscular – 2ml every 2 to 3 times. Intravenous -1 to 5 ml daily by slow i.v. Children- Oral – For 5 to 14 yrs – 30 to 60 mg/kg tab/day. Injection – For 3 to 4 months – 0.1ml i.m or slow i.v. every 4 times daily. For 1 to 4 yrs – 0.2 ml I.m or slow i.v every 4 times daily For 5 to 7 yrs -0.4 ml I.m or slow i.v every 4 times daily For 8 to 11 yrs – 0.5 ml I.m or slow i.v every 4 times daily For 12 to 14 yrs -0.8 ml I.m or slow i.v every 4 times daily |
| Schedule of Analgin |
| H |
| Storage Requirements for Analgin |
| Stored at room temperature away from light and moisture |
| Effects of Missed Dosage of Analgin |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Analgin |
| Empty the stomach. Given symptomatic and supportive treatment |