| Amisulpride Pharmacology |
| Amisulpride |
| About Amisulpride |
| D2 AND D3 antagonist, Atipsychotics. |
| Mechanism of Action of Amisulpride |
| Amisulpride is a substituted benzamide atypical antipsychotic with general properties similar to those of sulpiride and is reported to have a high affinity for dopamine D2 and D3 receptors. |
| Pharmacokinets of Amisulpride |
| Absorption: Absorbed after oral and intramuscular administration Distribution: Protein binding about 16% Excretion: Excreted through urine |
| Onset of Action for Amisulpride |
| N/A |
| Duration of Action for Amisulpride |
| N/A |
| Half Life of Amisulpride |
| 12 hrs |
| Side Effects of Amisulpride |
| 1.Weight gain 2.Dizziness 3.Postural hypotension 4.Eextrapyramidal symptoms 5.Neuroleptic Malignant syndrome 6.GI disorder |
| Contra-indications of Amisulpride |
| 1.Pheochromocytoma 2.Prolactin-dependent tumors |
| Special Precautions while taking Amisulpride |
| 1.Renal impairment 2.Parkinson’s disease 3.CV disease 4.History of epilepsy |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| N/A |
| Indications for Amisulpride |
| Acute psychosis |
| Interactions for Amisulpride |
| 1.Enhanced hypotensive and sedative effects when amisulpride given with opoid analgesics 2.Efficacy may be reduced by dopamine agonists |
| Typical Dosage for Amisulpride |
| 1.Oral: Adult: ?15 yr: 400-800 mg daily in 2 divided doses. Max: 1.2 g daily. For patients with predominantly negative symptoms: 50-300 mg daily 2.Intramuscular: Adult: 400 mg daily |
| Schedule of Amisulpride |
| N/A |
| Storage Requirements for Amisulpride |
| Store in a well closed container. Keep out of the reach of children. |
| Effects of Missed Dosage of Amisulpride |
| N/A |
| Effects of Overdose of Amisulpride |
| N/A |