| Aluminium Hydroxide Pharmacology |
| Aluminium Hydroxide |
| About Aluminium Hydroxide |
| Antacid,Antidote,Protectant( Topical), In hyperacidity; hyperphosphatemia. |
| Mechanism of Action of Aluminium Hydroxide |
| It neutralizes and reduces stomach acid relieving heartburn (acid reflux, GERD) and indigestion. This results increased pH and reduce the pepsin activity. It also binds to the phosphate in the gut and form a nonsoluble nonabsorbable aluminium phosphate complex. |
| Pharmacokinets of Aluminium Hydroxide |
| Absorption- Poorly absorbed.Excretion- Excreted through feces and breast milk |
| Onset of Action for Aluminium Hydroxide |
| N/A |
| Duration of Action for Aluminium Hydroxide |
| 20 to 180minutes |
| Half Life of Aluminium Hydroxide |
| N/A |
| Side Effects of Aluminium Hydroxide |
| 1. Loss of appetite 2. Constipation 3. Hypophosphatemia 4. Osteomalacia 5. Confusion 6. Unusual tiredness or discomfort 7. Muscle weakness 8. Encephalopathy |
| Contra-indications of Aluminium Hydroxide |
| 1. Hypersensitivity to the drug 2. Renal failure 3. Hypertension 4. Heart disease 5. Kidney disease 6. Gastrointestinal bleeding. |
| Special Precautions while taking Aluminium Hydroxide |
| 1. Stomach problems 2. Allergies |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| May be used |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| May be used |
| Indications for Aluminium Hydroxide |
| 1. Gastric hyperacidity 2. Ulcers 3. Digestive disorders 4. Hyperphosphatemia 5. Oesophagitis 6. Hiatal hernia 7. Gastritis |
| Interactions for Aluminium Hydroxide |
| N/A |
| Typical Dosage for Aluminium Hydroxide |
| Oral- Acidity and Hyperphosphatemia – Adult- 500-1500mg tablet or capsule 1 hr after meals and at bed time 5 to 30 ml suspension1 hr after meals and at bed time as needed |
| Schedule of Aluminium Hydroxide |
| N/A |
| Storage Requirements for Aluminium Hydroxide |
| Store it at room temperature and away from excess heat and moisture. Refrigerate the suspension. Do not freeze. |
| Effects of Missed Dosage of Aluminium Hydroxide |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Aluminium Hydroxide |
| Give symptomatic and supportive treatment |