| Alendronate Sodium Pharmacology |
| Alendronate Sodium |
| About Alendronate Sodium |
| Bisphosphonate Derivative, Bone resorption inhibitor. |
| Mechanism of Action of Alendronate Sodium |
| It preferentially localized to the sites of action and inhibits prenylation of GTP-binding proteins involved in cytoskeletal organization, membrane ruffling and vesicle movement. This results by osteoclasts inactivation, impaired vesicle fusion and enhanced apoptosis (bone resorption inhibition). |
| Pharmacokinets of Alendronate Sodium |
| Absorption- Poorly absorbed after oral administration Distribution- Widely distributed into soft tissues and then redistributed into bone.78% bound to the plasma proteins Metabolism- Doesn`t metabolized Excretion- Excreted through urine as unchanged form |
| Onset of Action for Alendronate Sodium |
| N/A |
| Duration of Action for Alendronate Sodium |
| N/A |
| Half Life of Alendronate Sodium |
| N/A |
| Side Effects of Alendronate Sodium |
| 1. Nausea. 2. Dyspepsia. 3. Abdominal cramps. 4. Flatulence. 5. Diarrhea. 6. Gastric and Duodenal ulceration. 7. Osteonecrosis 8. Skin rash. 9. Stevens-Johnson syndrome. 10. Epidermal necrolysis. 11. Uveitis. 12. Scleritis. |
| Contra-indications of Alendronate Sodium |
| 1. Hypersensitivity to the drug. 2. Dysphasia. 3. Symptomatic esophageal diseases. 4. Frequent heartburn. 5. Gastritis. 6. Gastro esophageal reflux disease 7. Hiatal hernia. 8. Ulcers. 9. Renal function. 10. Duodenitis. |
| Special Precautions while taking Alendronate Sodium |
| 1. Digestion problems. 2. Esophagus problems. 3. Intestine problems. 4. Stomach problems. 5. Kidney problems |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated. |
| Children Related Information |
| Use with caution |
| Indications for Alendronate Sodium |
| 1. Osteoporosis 2. Paget`s disease |
| Interactions for Alendronate Sodium |
| Asprin: Risks of upper GI adverse effects increased. Calcium supplements antacids: Interfere with absorption of alendronate. |
| Typical Dosage for Alendronate Sodium |
| Adult Oral- For osteoporosis:10-30mg daily For corticosteroid-induced osteoporosis: 5 – 10 mg daily Paget`s disease of bone: 40mg daily for 6 months All doses are taken with water at least 30 minutes before first food, beverage, or medication of the day |
| Schedule of Alendronate Sodium |
| H |
| Storage Requirements for Alendronate Sodium |
| Store at controlled room temperature. Keep away from light and moisture. |
| Effects of Missed Dosage of Alendronate Sodium |
| Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Alendronate Sodium |
| Give symptomatic and supportive treatment. Administer antacids or milk to prevent the adverse effects |