| Alclometasone dipropionate Pharmacology |
| Alclometasone dipropionate |
| About Alclometasone dipropionate |
| Adrenocorticoid (topical), anti-inflammatory, antipruritic, and vasoconstrictive. |
| Mechanism of Action of Alclometasone dipropionate |
| The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response. The drug exerts anti-inflammatory and immunosuppressant actions as follows: – 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. |
| Pharmacokinets of Alclometasone dipropionate |
| Absorption: After topical application small amount is absorbed. Distribution: It is distributed mainly in the skin. Small amount is distributed into muscle, skin, liver, intestine and kidney |
| Onset of Action for Alclometasone dipropionate |
| N/A |
| Duration of Action for Alclometasone dipropionate |
| N/A |
| Half Life of Alclometasone dipropionate |
| N/A |
| Side Effects of Alclometasone dipropionate |
| 1.Burning 2.Dryness 3.Irritation 4.Redness 5.Itching 6.Pruritus 7.Folliculitis |
| Contra-indications of Alclometasone dipropionate |
| 1.Hypersensitivity to Alclomethasone 2.Inflammation of corticosteroid responsive dermatoses |
| Special Precautions while taking Alclometasone dipropionate |
| 1.Skin infection |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| N/A |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| N/A |
| Indications for Alclometasone dipropionate |
| 1.Inflammations |
| Interactions for Alclometasone dipropionate |
| N/A |
| Typical Dosage for Alclometasone dipropionate |
| Apply the medicament as thin film in the affected area 2 – 3 times daily. Gently massage until medicaments disappears. |
| Schedule of Alclometasone dipropionate |
| N/A |
| Storage Requirements for Alclometasone dipropionate |
| Store the medicine at room temperature, away from heat and direct light. Keep the medicine out of the reach of children. |
| Effects of Missed Dosage of Alclometasone dipropionate |
| Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Alclometasone dipropionate |
| N/A |