| Adapalene Pharmacology |
| Adapalene |
| About Adapalene |
| Naphthoic acid derivative(a synthetic retinoid like compound), Anti-acne (Acne vulgaris). |
| Mechanism of Action of Adapalene |
| Adapalene is a chemically stable retinoid-like compound and is a derivative of naphthoic acid. Adapalene binds to specific retinoic acid nuclear receptors and it normalizes differentiation of follicular epithelial cells resulting in decreased comedones (black and white heads) formation. Adapalene inhibits the chemotactic (directional) and chemo kinetic (random) responses of human polymorphonuclear leucocytes and also inhibits the formation of inflammatory mediators by inhibiting metabolism of arachidonic acid. Adapalene also modulates cellular differentiation, keratinization, and inflammatory processes. |
| Pharmacokinets of Adapalene |
| Absorption: Absorption after topical administration is minimal |
| Onset of Action for Adapalene |
| N/A |
| Duration of Action for Adapalene |
| N/A |
| Half Life of Adapalene |
| N/A |
| Side Effects of Adapalene |
| 1.Irritation 2.Scaling 3.Erythema 4.Dryness 5.Stinging 6.Burning 7.Pruritis 8.Redness |
| Contra-indications of Adapalene |
| Hypersensitivity to Adapalene |
| Special Precautions while taking Adapalene |
| 1. Eczema 2. Sun burn 3.Avoid contact with eyes, mucous membrane ,lips, nose, wounds, abrasions, scaly skins 4.Avoid exposure to sunlight and ultraviolet light 5.Use a sunscreen and protective clothing if sun exposure is unavoidable 6.Avoid preparations containing sulphur, Resorcinol, or salicylic acid 7.Avoid occlusive dressing |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Use with caution Below12 years: contraindicated NEONATES: contraindicated |
| Indications for Adapalene |
| Acne vulgaris |
| Interactions for Adapalene |
| Topical products with a potential for irritation (medicated or abrasive soaps, and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime), particularly preparations containing sulphur, resorcinol, or salicylic acid in combination with adapalene: Exercise caution with concomitant use of adapalene. |
| Typical Dosage for Adapalene |
| Adapalene 0.1% gel is used. Clean and dry the affected area and apply the medicament once daily (at night) for 3 months for acne and 1-4 weeks for psoriasis |
| Schedule of Adapalene |
| H |
| Storage Requirements for Adapalene |
| Store at room temperature away from moisture and heat. Keep out of the reach of children |
| Effects of Missed Dosage of Adapalene |
| Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Adapalene |
| Give supportive measures and symptomatic treatment. |