| Acebutolol Pharmacology |
| Acebutolol |
| About Acebutolol |
| Cardio selective beta blocker, Antihypertensive,Antiarrhythmias |
| Mechanism of Action of Acebutolol |
| Acebutolol is a cardioselective ?-adrenergic antagonist with little effect on the bronchial receptors. It exhibits some intrinsic sympathomimetic activity and membrane-stabilizing properties.It decreases oxygen consumption and cardiac work.It prevent the release of rennin.It reduces blood pressure.Acebutolol also act as antiarrythmic agent due to beta blocking action. |
| Pharmacokinets of Acebutolol |
| Absorption: Absorbed after oral administration Distribution: Distributed in the body,crosses blood brain barrier Metabolism: Metabolised in the liver Excretion: Excreted through urine |
| Onset of Action for Acebutolol |
| 1 to 3 hrs |
| Duration of Action for Acebutolol |
| 12 to 24 hrs |
| Half Life of Acebutolol |
| 3 to 4 hrs |
| Side Effects of Acebutolol |
| 1.Fatigue 2.Bradycardia 3.Heart block 4.Bronchospasm 5.GI disturbances 6.Male impotence 7.Skin rash 8.Muscle cramps |
| Contra-indications of Acebutolol |
| 1.Hypersensitivity to beta blockers 2.Asthma 3.Heart block greater than first degree 4.Insulin dependent diabetics with frequent hypoglycemic episode 5.Overt heart failure 6.Severe bradycardia |
| Special Precautions while taking Acebutolol |
| 1.Kidney diseases 2.Liver diseases 3.Diabetes 4.Angina 5.Heart failure 6.Hyperthyroidism |
| Pregnancy Related Information |
| Use with caution |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Acebutolol |
| 1.Hypertension 2.Ventricular and atrial cardiac arrhythmia 3.Acute myocardial infarction In high risk patients 4.Smith-Magenis syngrome |
| Interactions for Acebutolol |
| Clonidine: May enhance or reverse acebutolol`s antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal NSAIDs: Some agents may impair antihypertensive effect Prazosin: May cause increase in orthostatic hypotension Verapamil: Effects of both drugs may be increased |
| Typical Dosage for Acebutolol |
| Hypertension: Adult: Initially, 400 mg once daily or 200 mg bid. If necessary, may increase dose after 2 wk to 400 mg bid. Up to 1.2 g daily Angina pectoris: Adult: 400 mg once daily or 200 mg bid up to 300 mg tid. Up to 1.2 g daily Cardiac arrhythmias: Adult: Initially, 200 mg bid up to 1.2 g daily in divided doses as required |
| Schedule of Acebutolol |
| H |
| Storage Requirements for Acebutolol |
| Store at controlled room temperature of 20?C to 25?C (68?F to 77?F). Protect from light and dispense in a light-resistant, tight container.Keep out of the reach of children |
| Effects of Missed Dosage of Acebutolol |
| N/A |
| Effects of Overdose of Acebutolol |
| N/A |
| Acebrophylline Pharmacology |
| Acebrophylline |
| About Acebrophylline |
| Bronchodilator, Mucoregulator, Antiinflamatory drug,salt of theophylline-7- acetic acid with ambroxol. |
| Mechanism of Action of Acebrophylline |
| Theophylline-7-acetate ha bronchodilator effect due to inhibition of the intracellular phosphodiesterases, followed by increase in cyclic AMP level which promote the relaxation of bronchial muscles. Ambroxol act as a mucolytic agent by increases the mucociliary clearance by stimulating cilia motility. Acebrophylline inhibit the synthesis and release of leukotrienes and tumoir necrosis factor and reduces inflammation. |
| Pharmacokinets of Acebrophylline |
| Absorption: Absorbed after oral administration Distribution: Widely distributed in the body Metabolism: Metabolised in the liver Excretion: Excreted through urine |
| Onset of Action for Acebrophylline |
| 1 to 2 hours |
| Duration of Action for Acebrophylline |
| N/A |
| Half Life of Acebrophylline |
| 4 to 9 hours |
| Side Effects of Acebrophylline |
| 1.Abdominal discomfort 2.Stomach/abdominal distension 3.Vomiting 4.Diarrhea 5.Constipation 6.Esophageal bleeding |
| Contra-indications of Acebrophylline |
| 1.Hypersensitivity to ambroxol and xanthine derivative 2.Myocardial infraction 3.Hypotension 4.Renal disease 5.Liver disorder 6.Hemodynamic instability and arrhythmias |
| Special Precautions while taking Acebrophylline |
| 1.Cardiac insufficiency 2.Gastro intestinal disorders 3.Epilepsy and hyperthyroidism |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| Use with caution |
| Indications for Acebrophylline |
| 1.COPD 2.Bronchial asthma 3.Bronchitis 4.Sinusitis |
| Interactions for Acebrophylline |
| The concomitant use of acebrophylline and frusimide can potentiate dieresis Concomitant use of acebrophylline with reserpine can cause tachycardia Phenytoin and barbiturates decreases the plasma concentration of acebrophylline |
| Typical Dosage for Acebrophylline |
| Adult : 100 mg twice daily Children up to 2 years, it`s half a teaspoon, twice daily. Age 2 to 5 is half a teaspoon, three times a day Children age over 5, its a teaspoon 2 to 3 times a day. |
| Schedule of Acebrophylline |
| H |
| Storage Requirements for Acebrophylline |
| Store in a cool dry place and protect from light. Keep out of the reach of children |
| Effects of Missed Dosage of Acebrophylline |
| N/A |
| Effects of Overdose of Acebrophylline |
| N/A |