| Abciximab Pharmacology |
| Abciximab |
| About Abciximab |
| Glycoprotein IIb/IIIa Inhibitor, Antiplatelet Agent. |
| Mechanism of Action of Abciximab |
| It is a monoclonal antibody which inhibits glycoprotein IIa/IIIa receptor. It exerts it`s action by steric hindrance of the receptor itself and prevents platelet aggregation and subsequent thrombus formation and blocking interaction of fibrinogen. It also inhibits vitronectin receptor which mediates both platelet coagulation as well as endothelial and vascular smooth muscle proliferation. It is an effective drug in the treatment of acute coronary syndromes. |
| Pharmacokinets of Abciximab |
| It is administered intravenously |
| Onset of Action for Abciximab |
| N/A |
| Duration of Action for Abciximab |
| 12 to 24 hour |
| Half Life of Abciximab |
| 10 to 30minutes |
| Side Effects of Abciximab |
| 1.Haemorrhage 2.Thrombocytopenia 3.Allergic reactions 4.Arrhythmias 5.Constipation 6.Ileus 7.Bradycardia 8.Atrial fibrillation 9.Atrial flutter 10.AV block 11.Dizziness 12.Supraventricular tachycardia 13.Hypotension 14.Headache 15.Abnormal tinking 16.Confusion 17.Nausea 18.Vomiting 19.Fever 20.Oedema 21.Pruritus |
| Contra-indications of Abciximab |
| 1.Hypersensitivity to the drug 2.Thrombocytopenia 3.Bleeding diathesis 4.Bleeding disorders 5.Gastro intestinal tract ulceration 6.Ulcerative wounds 7.History of vasculitis 8.Severe hypertension 9.Increased capillary permeability 10.Possible internal injuries 11Cerebrovascular haemorrhage 12.Intracranial neoplasm 13.Administration of oral anticoagulant within 7days 14.Surgery within 10days 15.10days postpartum 16.Renal impairment 17.Hepatic impairment |
| Special Precautions while taking Abciximab |
| Use cautiously in following condition 1.Renal diseases 2.Liver diseases 3.Recent thrombolytic therapy 4.Use low dose regimen on a weight basis 5.Give careful attention to all potential bleeding sites during administration. |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Use with caution |
| Children Related Information |
| Contraindicated |
| Indications for Abciximab |
| 1.Adjunct to percutaneous transluminal coronary angioplasty, 2.Unstable angina |
| Interactions for Abciximab |
| Use of thrombolytics, anticoagulants and other antiplatelet agents along with Abciximab may result in increased bleeding. |
| Typical Dosage for Abciximab |
| Adjunct to percutaneous transluminal coronary angioplasty: 250mcg/kg I.V. bolus 10 to 60minutes prior to the procedure followed by 0.125mcg/kg/minute infused for 12 hours (maximum dose: 10mcg/minute infusion) Unstable angina: 0.25mg/kg I.V. bolus followed by an infusion of 0.125mcg/kg/minute for 18 to 24 hours. |
| Schedule of Abciximab |
| C |
| Storage Requirements for Abciximab |
| Store at a temperature range of 2 to 8 degree C. Avoid freezing |
| Effects of Missed Dosage of Abciximab |
| The doctor should be informed immediately if a dose is missed |
| Effects of Overdose of Abciximab |