|
Abacavir Pharmacology |
| Abacavir |
| About Abacavir |
| Reverse Transcriptase Inhibitor (Nucleoside), Antiretroviral Agent. |
| Mechanism of Action of Abacavir |
| Abacavir is a guanosine nucleoside analogue. It undergoes phosphorylation in the presence of phosphotransferase and Kinase enzyme and form Carbovir triphosphate. This Carbovir triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and it is then added to host cell chromosome Carbovir triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. |
| Pharmacokinets of Abacavir |
| Absorption: It is rapidly and extensively absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes intracellular metabolism to the active antiviral metabolite Carbovir triphosphate. Excretion: It is excreted mainly in urine. |
| Onset of Action for Abacavir |
| N/A |
| Duration of Action for Abacavir |
| N/A |
| Half Life of Abacavir |
| 60 – 120 minutes |
| Side Effects of Abacavir |
| 1.Nausea 2.Vomiting 3.Diarrhoea 4.Anorexia 5.Malaise 6.Fever 7.Pruritis 8.Rash 9.Headache 10.Pharyngitis 11.Cough |
| Contra-indications of Abacavir |
| Hypersensitivity to Abacavir |
| Special Precautions while taking Abacavir |
| 1.Renal impairment 2.Hepatic impairment (Hepatomegaly, Lactic acidosis) |
| Pregnancy Related Information |
| Contraindicated |
| Old Age Related Information |
| Use with caution |
| Breast Feeding Related Information |
| Contraindicated |
| Children Related Information |
| May be used NEONATES: Contraindicated |
| Indications for Abacavir |
| HIV infection in combination with other antiretroviral drugs. |
| Interactions for Abacavir |
| Analgesics: Plasma concentration of methadone possibly decreased by abacavir. |
| Typical Dosage for Abacavir |
| Adult: 600 mg / day in 2 divided doses combine with other antiretroviral agents. Children: 16 mg / kg body weight / day in 2 divided doses |
| Schedule of Abacavir |
| H |
| Storage Requirements for Abacavir |
| Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children. |
| Effects of Missed Dosage of Abacavir |
| Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose. |
| Effects of Overdose of Abacavir |
| Give supportive measures and treatment. |